HARD IONIZATION AND SOFT IONIZATION


Ionization refers to the generation of gas phase ions appropriate for resolution in a mass analyzer or mass filter in mass spectrometry. The ion source is where ionization takes place. There are a variety of ion sources accessible, each with its own set of benefits and drawbacks for certain applications.  For example, electron ionization (EI) causes a high degree of fragmentation, resulting in highly detailed mass spectra that, when properly analyzed, can provide valuable information for structural elucidation/characterization and aid in the identification of unknown compounds by comparing them to mass spectral libraries obtained under identical operating conditions.


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