Mass Spectrometry and Chromatography

Mass Spectrometry Instrumentation

A Mass Spectrometer produces ions from the sample under inquiry, separates them based on their mass-to-charge ratio (m/z), and then records the relative abundance of each ion type. The instrument is made up of three main parts. Analyzer, Detector System, and Ion Source The operations should always be carried out by a mass spectrometer.

In the ionisation source, generate ions from the sample. In the mass analyzer, separate these ions according to their mass-to-charge ratio. Fragment the selected ions and analyse the fragments in a second analyser at the end. Using the detector that converts ions into electrical signals, detect the ions emerging from the last analyzer and measure their abundance. Process the detector signals that are sent to the computer and use feedback to control the instrument